Voxtalisib (Standard)
Voxtalisib (Standard) is the analytical standard of Voxtalisib. This product is intended for research and analytical applications. Voxtalisib (XL765) is a potent PI3K inhibitor, which has a similar activity toward class I PI3K (IC50s=39, 113, 9 and 43 nM for p110α, p110β, p110γ and p110δ, respectively), also inhibits DNA-PK (IC50=150 nM) and mTOR (IC50=157 nM) . Voxtalisib (XL765) inhibits mTORC1 and mTORC2 with IC50s of 160 and 910 nM, respectively.
Product Specifications
CAS Number
934493-76-2
UNSPSC
12352100
Target
MTOR; PI3K; Reference Standards
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC
Molecular Formula
C13H14N6O
Molecular Weight
270.29
References & Citations
[1]Garcia-Echeverria C, et al. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. 2008 Sep 18;27 (41) :5511-26.|[2]Yu P, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014 May;13 (5) :1078-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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