GE1111
GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC50 of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC50 of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 -induced systemic allergic reaction model[1].
Product Specifications
CAS Number
2883669-12-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Purity
95.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=CC1=CC2=C3C(C1C)=C(O)C=CC3=CC(C4=CC5=C(C=C4C(OC)=O)C=C(NC(N)=O)C=C5)=C2
Molecular Formula
C28H22N2O5
Molecular Weight
466.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Kumar M, et al., Mrgprx2 antagonist for the treatment of pseudo allergic reactions. US20220401435
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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