GE1111

GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC50 of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC50 of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 (HY-130592) -induced systemic allergic reaction model[1].

Product Specifications

CAS Number

[2883669-12-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Purity

95.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=CC1=CC2=C3C(C1C)=C(O)C=CC3=CC(C4=CC5=C(C=C4C(OC)=O)C=C(NC(N)=O)C=C5)=C2

Molecular Formula

C28H22N2O5

Molecular Weight

466.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Kumar M, et al., Mrgprx2 antagonist for the treatment of pseudo allergic reactions. US20220401435

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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