Penicinoline

Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells[1][2].

Product Specifications

CAS Number

[1214268-60-6]

Product Name Alternative

Marinamide

UNSPSC

12352005

Target

Endogenous Metabolite; Parasite

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Smiles

O=C(C1=C(C2=CC=CN2)NC3=C(C=CC=C3)C1=O)O

Molecular Formula

C14H10N2O3

Molecular Weight

254.24

References & Citations

[1]Shao CL, et al. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg Med Chem Lett. 2010 Jun 1;20 (11) :3284-6.|[2]Naveen B, et al. Total synthesis of penicinoline E, marinamide, methyl marinamide and their antimalarial activity[J]. ChemistrySelect, 2017, 2 (11) : 3256-3261.