TG11-77 (hydrochloride)

TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit[1][2].

Product Specifications

CAS Number

[2550393-38-7]

UNSPSC

12352005

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease; Inflammation/Immunology

Smiles

O=C(C1=CN=C(NC2=CC(C)=CC(C)=N2)N=C1)NCCC3=C(C)NC4=C3C=CC=C4.Cl

Molecular Formula

C23H25ClN6O

Molecular Weight

436.94

References & Citations

[1]Amaradhi R, et al. Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. J Med Chem. 2020 Feb 13;63 (3) :1032-1050. |[2]Varvel NH, et al. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 2023 Feb 15;224:109356.