TG11-77 (hydrochloride)
TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit[1][2].
Product Specifications
CAS Number
2550393-38-7
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease; Inflammation/Immunology
Smiles
O=C(C1=CN=C(NC2=CC(C)=CC(C)=N2)N=C1)NCCC3=C(C)NC4=C3C=CC=C4.Cl
Molecular Formula
C23H25ClN6O
Molecular Weight
436.94
References & Citations
[1]Amaradhi R, et al. Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. J Med Chem. 2020 Feb 13;63 (3) :1032-1050. |[2]Varvel NH, et al. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 2023 Feb 15;224:109356.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
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