Revefenacin-d3
Revefenacin-d3 (TD-4208-d3) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
Product Specifications
Product Name Alternative
TD-4208-d3; GSK1160724-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; mAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(OC1CCN(CCN(C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)C([2H])([2H])[2H])CC1)NC4=CC=CC=C4C5=CC=CC=C5
Molecular Formula
C35H40D3N5O4
Molecular Weight
600.77
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Steinfeld T, et al. In vitro characterization of TD-4208, a lung-selective and long-acting muscarinic antagonist bronchodilator (Abstract) . Am J Respir Crit Care Med 179:A4553.|[3]Pulido-Rios MT, et al. In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models. J Pharmacol Exp Ther. 2013 Aug;346 (2) :241-50.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470633-500 1x 500 µL
Von Willebrand Factor (3E2D10), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470031-500 1x 500 µL
Mucin 5AC (MUC5AC) (45M1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940040-500 1x 500 µL
CD35 / CR1 (E11), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682644-500 1x 500 µL
Prolactin (Pituitary Tumor Marker) (PRL/2644), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details