PROTAC EGFR degrader 13
PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer (Pink: Target protein ligand; Blue: E3 ligand ; Black: linker (HY-W262798) ; E3 ligand + linker: HY-W998306).
Product Specifications
CAS Number
2861227-35-0
UNSPSC
12352005
Target
EGFR; PROTACs
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Molecular Formula
C49H55BrN11O6P
Molecular Weight
1004.91
References & Citations
[1]Chen Zhang, et al. Phosphonyl derivative, and composition and pharmaceutical application thereof. WO2022228547A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Uncoated Mouse TNFRSF5 (Tumor necrosis factor receptor superfamily member 5) ELISA Kit
Uncoated Mouse TNFRSF5 (Tumor necrosis factor receptor superfamily member 5) ELISA Kit
