PROTAC EGFR degrader 13
PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-14658) ; Black: linker (HY-W262798) ; E3 ligand + linker: HY-W998306) [1].
Product Specifications
CAS Number
[2861227-35-0]
UNSPSC
12352005
Target
EGFR; PROTACs
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Molecular Formula
C49H55BrN11O6P
Molecular Weight
1004.91
References & Citations
[1]Chen Zhang, et al. Phosphonyl derivative, and composition and pharmaceutical application thereof. WO2022228547A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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