(Rac) -Ibrutinib alkyne
(Rac) -Ibrutinib alkyne (Compound 8) is a Btk inhibitor with an IC50 of 0.72 nM. (Rac) -Ibrutinib alkyne can effectively inhibit functions related to the B-cell receptor signaling pathway, with an IC50 of 9 nM for inhibiting Ca flux in Ramos cells. (Rac) -Ibrutinib alkyne can be used in the research of diseases such as rheumatoid arthritis[1].
Product Specifications
CAS Number
[936563-91-6]
UNSPSC
12352005
Target
Btk; Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CC(N1CC(N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O
Molecular Formula
C25H22N6O2
Molecular Weight
438.48
References & Citations
[1]Pan Z, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2 (1) :58-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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