MR24 (TFA)
MR24 TFA, a G-5555 derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers[1].
Product Specifications
UNSPSC
12352005
Target
Hippo (MST)
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.13
Smiles
CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1.OC(C(F)(F)F)=O
Molecular Formula
C28H30ClF3N6O5
Molecular Weight
623.02
References & Citations
[1]Rak M, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7 (8H) -one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J Med Chem. 2024 Mar 14;67 (5) :3813-3842.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MST3; MST4
Available Sizes
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