MR24 (TFA)

MR24 TFA, a G-5555 derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers[1].

Product Specifications

UNSPSC

12352005

Target

Hippo (MST)

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.13

Smiles

CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1.OC(C(F)(F)F)=O

Molecular Formula

C28H30ClF3N6O5

Molecular Weight

623.02

References & Citations

[1]Rak M, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7 (8H) -one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J Med Chem. 2024 Mar 14;67 (5) :3813-3842.