Ellipticine (hydrochloride) (Standard)

Ellipticine (hydrochloride) (Standard) is the analytical standard of Ellipticine (hydrochloride) . This product is intended for research and analytical applications. Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

Product Specifications

CAS Number

[5081-48-1]

UNSPSC

12352100

Target

Reference Standards; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4.Cl

Molecular Formula

C17H15ClN2

Molecular Weight

282.77

References & Citations

[1]Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150 (1) :13-23.|[2]Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4 (2) :98-105.|[3]Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16 (1) :284-306.