PSI-7409 (tetrasodium)

PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.

Product Specifications

CAS Number

[1621884-22-7]

UNSPSC

12352005

Target

HCV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.31

Solubility

H2O : ≥ 100 mg/mL

Smiles

O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H12FN2Na4O14P3

Molecular Weight

588.09

References & Citations

[1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54 (8) :3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285 (45) :34337-47.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Asian J Pharm Sci. 2021 Nov;16 (6) :772-783.|J Med Chem. 2025 Jun 26;68 (12) :12414-12433.|Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2023 Jan 22:641:50-56.|Cell. 2022 Nov 10;185 (23) :4347-4360.e17.|J Virol Methods. 2021 Dec:298:114283.|Microbiol Spectr. 2022 Oct 26;10 (5) :e0272922.