1,2-Dierucoyl-sn-glycero-3-PE

1,2-Dierucoyl-sn-glycero-3-PE (1,2-Dierucoyl-sn-3-phosphatidylethanolamine) is a phospholipid that contains erucic acid. 1,2-Dierucoyl-sn-glycero-3-PE can be used in the generation of lipid nanoparticles (LNPs) to deliver mRNA in vivo. 1,2-Dierucoyl-sn-glycero-3-PE can also be used to synthesize numerous PEG-conjugates for liposomes incorporation[1][2][3][4].

Product Specifications

CAS Number

[904304-57-0]

Product Name Alternative

1,2-Dierucoyl-sn-3-phosphatidylethanolamine; di22:1-PE; PE (22:1/22:1)

UNSPSC

12352211

Target

Liposome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

CCCCCCCC/C=C\CCCCCCCCCCCC(O[C@@H](COP(OCCN)(O)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O

Molecular Formula

C49H94NO8P

Molecular Weight

856.25

References & Citations

[1]Vaidya, A., et al., (2024) . Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation. Analytical chemistry, 96 (14), 5570–5579.|[2]Longmuir, K. J., et al., (2006) . Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharmaceutical research, 23 (4), 759–769.|[3]Haynes, S. M., et al., (2008) . Liposomal polyethyleneglycol and polyethyleneglycol-peptide combinations for active targeting to liver in vivo. Drug delivery, 15 (4), 207–217. |[4]Tsai, M. S., et al., (2011) . Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity. Journal of drug targeting, 19 (7), 506–515.