Ansamitocin P-3 (Standard)

Ansamitocin P-3 (Standard) is the analytical standard of Ansamitocin P-3. This product is intended for research and analytical applications. Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

Product Specifications

CAS Number

[66584-72-3]

Product Name Alternative

Antibiotic C 15003P3 (Standard) ; Maytansinol isobutyrate (Standard)

UNSPSC

12352005

Target

ADC Payload; Antibiotic; Bacterial; Microtubule/Tubulin; Reference Standards

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton; Others

Field of Research

Cancer; Infection

Smiles

ClC1=C(N(C)C(C[C@H](OC(C(C)C)=O)[C@@](O2)(C)[C@]2([H])[C@H](C)[C@]3([H])C[C@](NC(O3)=O)(O)[C@H](OC)/C=C/C=C(C)/C4)=O)C=C4C=C1OC

Molecular Formula

C32H43ClN2O9

Molecular Weight

635.14

References & Citations

[1]Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48 (5) :1739-48|[2]Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8 (10) :e75182.