Estetrol-d4 (Major)
Estetrol-d4 (Major) is the deuterium labeled Estetrol (HY-15731) . Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol binds ERα as well as ERβ (with a fourfold lower affinity) . Estetrol increases eNOS expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research[1][2][3][4].
Product Specifications
CAS Number
[2734920-42-2]
UNSPSC
12352005
Target
Endogenous Metabolite; Estrogen Receptor/ERR; Isotope-Labeled Compounds; NO Synthase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
[2H]C1=C(C([2H])=C(C2=C1)C([2H])(C[C@@]3([C@@]2(CC[C@]4([C@]3([C@H]([C@H]([C@@H]4O)O)O)[H])C)[H])[H])[2H])O
Molecular Formula
C18H20D4O4
Molecular Weight
308.41
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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