(Rac) -GSK866
(Rac) -GSK866 (GSK47866A) is a non-steroidal glucocorticoid receptor (GR) ligand. The crystal structure of (Rac) -GSK866 bound to the GR LBD (3E7C) can be used as a model to study the mechanism of action of ligands of the same class[1].
Product Specifications
CAS Number
960248-81-1
Product Name Alternative
GSK47866A
UNSPSC
12352005
Target
Glucocorticoid Receptor
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Smiles
O=C(C1=C(N)N(C2=CC=C(C=C2)F)N=C1)NCC(CN(CC)C(C3=C(Cl)C=CC=C3Cl)=O)(C(F)(F)F)O
Molecular Formula
C23H21Cl2F4N5O3
Molecular Weight
562.34
References & Citations
[1]Trebble PJ, et al. A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function. J Cell Sci. 2013 Jul 15;126 (Pt 14) :3159-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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