(Rac) -GSK866

(Rac) -GSK866 (GSK47866A) is a non-steroidal glucocorticoid receptor (GR) ligand. The crystal structure of (Rac) -GSK866 bound to the GR LBD (3E7C) can be used as a model to study the mechanism of action of ligands of the same class[1].

Product Specifications

CAS Number

[960248-81-1]

Product Name Alternative

GSK47866A

UNSPSC

12352005

Target

Glucocorticoid Receptor

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Smiles

O=C(C1=C(N)N(C2=CC=C(C=C2)F)N=C1)NCC(CN(CC)C(C3=C(Cl)C=CC=C3Cl)=O)(C(F)(F)F)O

Molecular Formula

C23H21Cl2F4N5O3

Molecular Weight

562.34

References & Citations

[1]Trebble PJ, et al. A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function. J Cell Sci. 2013 Jul 15;126 (Pt 14) :3159-69.