NSC 23766 (trihydrochloride) (Standard)

NSC 23766 (trihydrochloride) (Standard) is the analytical standard of NSC 23766 (trihydrochloride) . This product is intended for research and analytical applications. NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.

Product Specifications

CAS Number

[1177865-17-6]

UNSPSC

12352100

Target

Apoptosis; Ras; Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

NC1=CC(C)=NC2=CC=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C12.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C24H38Cl3N7

Molecular Weight

530.96

References & Citations

[1]Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39 (2) :760-7.|[2]Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415|[3]Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972|[4]Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173 (5) :937-50