LP-6 (TFA)
LP-6 TFA is a Drug-Linker Conjugate for ADC, and can be used for synthesis of ADCs. LP-6 TFA consists of an Eg5 inhibitor and a linker[1].
Product Specifications
CAS Number
1629741-09-8
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; Kinesin
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Purity
99.61
Smiles
F[C@@H](CNC1)[C@@H]1CN(C([C@@H](O)C)=O)[C@@H](C2=NC(C3=C(C=CC(F)=C3)F)=CN2CC4=CC=CC=C4)C(C)(C)CC(NCCN5C(C=CC5=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C36H41F3N6O5·xC2HF3O2
Molecular Weight
694.74 (free base)
References & Citations
[1]Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10 (12) :1674-1679.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP
Frequently Asked Questions
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