AP736
AP736 is a potent tyrosinase inhibitor (IC50 = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes (IC50 = 0.11 μM) . AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research[1][2].
Product Specifications
CAS Number
1365531-21-0
UNSPSC
12352005
Target
PKA; Tyrosinase
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Others
Smiles
O=C(C1=C(OC)C=C(OC)C(C23CC4CC(C3)CC(C2)C4)=C1)NCC5=CC=C(C=C5O)O
Molecular Formula
C26H31NO5
Molecular Weight
437.53
References & Citations
[1]Shin HJ, et al. Development and evaluation of topical formulations for a novel skin whitening agent (AP736) using Hansen solubility parameters and PEG-PCL polymers. Int J Pharm. 2018 Dec 1;552 (1-2) :251-257.|[2]Lee CS, et al. A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression. Exp Dermatol. 2013 Nov;22 (11) :762-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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