Zibrofusidic acid

Zibrofusidic acid (24-Bromofusidic acid; TD-1414) is a brominated derivative of Fusidic acid (HY-B1350) . Zibrofusidic acid can be combined within the hydrophobic groove formed by the transmembrane helix 1 (TM1) and the transmembrane helix 2 (TM2) of the AcrB protein. Zibrofusidic acid can be used for the research of multidrug efflux pump[1].

Product Specifications

CAS Number

[827603-95-2]

Product Name Alternative

24-Bromofusidic acid; TD-1414

UNSPSC

12352211

Target

Drug Derivative

Related Pathways

Others

Field of Research

Others

Smiles

C[C@@]([C@](C[C@H]1O)([H])/C2=C(C(O)=O)\CC/C(Br)=C(C)/C)(C[C@@H]2OC(C)=O)[C@]([C@]1([H])[C@]3(CC[C@H]4O)C)(CC[C@@]3([H])[C@@H]4C)C

Molecular Formula

C31H47BrO6

Molecular Weight

595.61

References & Citations

[1]Oswald C, et al. Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB. Nat Commun. 2016 Dec 16;7:13819.