PF-04455242
PF-04455242 is a high-affinity, selective κ-opioid receptor antagonist, with an average Ki value of 3.0 nM for human κ-opioid receptor. PF-04455242 blocks analgesia. PF-04455242 demonstrates antidepressant-like efficacy, attenuates the behavioral effects of stress[1].
Product Specifications
CAS Number
1202647-54-8
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=S(C1=CC=CC=C1C2=CC=C(CNCC(C)C)C=C2)(N3CCCC3)=O
Molecular Formula
C21H28N2O2S
Molecular Weight
372.52
References & Citations
[1]Grimwood S, et al. Pharmacological characterization of 2-methyl-N- ((2'- (pyrrolidin-1-ylsulfonyl) biphenyl-4-yl) methyl) propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors. J Pharmacol Exp Ther. 2011 Nov;339 (2) :555-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR
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