Cav 3.1 blocker 1
Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC50value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC50 of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC50 of >10000 nM) [1].
Product Specifications
CAS Number
2158201-04-6
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=NN(C(C2=CC=CC=C2)=C1C(F)F)C3=CC=C(C=C3)F)NCC4=C(OCC(F)(F)F)C=CC=C4
Molecular Formula
C26H19F6N3O2
Molecular Weight
519.44
References & Citations
[1]Bezençon O, et al. Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies. Chimia (Aarau) . 2017 Oct 25;71 (10) :722-729.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
T-type calcium channel
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