MTX-216
MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma[1].
Product Specifications
CAS Number
[1952236-19-9]
UNSPSC
12352005
Target
Apoptosis; EGFR; PI3K; Syk
Related Pathways
Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N#CC1=C(NC2=CC=C(C(Cl)=C2)F)C3=CC(C4=CC(NS(=O)(C)=O)=C(Cl)N=C4)=CC=C3N=C1
Molecular Formula
C22H14Cl2FN5O2S
Molecular Weight
502.35
References & Citations
[1]Cara Abecunas, et al. Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition. Cancer Res. 2023 Jan 18;83 (2) :316-331.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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