ST09
ST09 is an efficient and low toxicity curcumin derivative. ST09 significantly inhibits cell migration and downregulates the expression of MMP1, MMP2, and Vimentin. ST09 has strong cytotoxicity to breast cancer cells, such as MDA-MB-231, MCF7 and T47D cells. ST09 induces cell apoptosis by upregulating Bax and cleaved caspase-3/9. ST09 can be used in the research of cancer such as breast cancer[1].
Product Specifications
CAS Number
1370037-59-4
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; MMP
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(SCCC(NCCCCCCNC1=C(C=CC(Cl)=C2)C2=NC3=C1CCCC3)=O)=O
Molecular Formula
C24H32ClN3O2S
Molecular Weight
462.05
References & Citations
[1]Wang, Yue; Guan, Xin-Lei; Wu, Peng-Fei; et al. Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases. Journal of Medicinal Chemistry (2012), 55 (7), 3588-3592.|[2]Nirgude S, et al. ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models. Molecules. 2020 Sep 30;25 (19) :4499.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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