ST09

ST09 is an efficient and low toxicity curcumin derivative. ST09 significantly inhibits cell migration and downregulates the expression of MMP1, MMP2, and Vimentin. ST09 has strong cytotoxicity to breast cancer cells, such as MDA-MB-231, MCF7 and T47D cells. ST09 induces cell apoptosis by upregulating Bax and cleaved caspase-3/9. ST09 can be used in the research of cancer such as breast cancer[1].

Product Specifications

CAS Number

[1370037-59-4]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; MMP

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(SCCC(NCCCCCCNC1=C(C=CC(Cl)=C2)C2=NC3=C1CCCC3)=O)=O

Molecular Formula

C24H32ClN3O2S

Molecular Weight

462.05

References & Citations

[1]Wang, Yue; Guan, Xin-Lei; Wu, Peng-Fei; et al. Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases. Journal of Medicinal Chemistry (2012), 55 (7), 3588-3592.|[2]Nirgude S, et al. ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models. Molecules. 2020 Sep 30;25 (19) :4499.