OSI-413 (free base)
OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1][2].
Product Specifications
CAS Number
183320-29-8
Product Name Alternative
CP 373413
UNSPSC
12352005
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
OCCOC1=C(OCCOC)C=C2C(N=CN=C2NC3=CC(C#C)=CC=C3)=C1
Molecular Formula
C21H21N3O4
Molecular Weight
379.41
References & Citations
[1]Takuya Ishida, et al. Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. Biomed Chromatogr|[2]Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57 (21), 4838-4848.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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