OSI-413 (free base)

OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896) . Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1][2].

Product Specifications

CAS Number

[183320-29-8]

Product Name Alternative

CP 373413

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

OCCOC1=C(OCCOC)C=C2C(N=CN=C2NC3=CC(C#C)=CC=C3)=C1

Molecular Formula

C21H21N3O4

Molecular Weight

379.41

References & Citations

[1]Takuya Ishida, et al. Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. Biomed Chromatogr|[2]Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57 (21), 4838-4848.