Wnt-C59 (Standard)
Wnt-C59 (Standard) is the analytical standard of Wnt-C59. This product is intended for research and analytical applications. Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
Product Specifications
CAS Number
[1243243-89-1]
UNSPSC
12352100
Hazard Statement
H302, H315, H319, H335
Target
Porcupine; Reference Standards; Wnt
Related Pathways
Others; Stem Cell/Wnt
Field of Research
Cancer
Purity
99.80
Smiles
O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3
Molecular Formula
C25H21N3O
Molecular Weight
379.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73 (2) :502-7.|[2]Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6 (16) :14428-39.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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