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Alvelestat (Standard)

Alvelestat (Standard) is the analytical standard of Alvelestat. This product is intended for research and analytical applications. Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].

Product Specifications

CAS Number

848141-11-7

UNSPSC

12352100

Target

Elastase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4

Molecular Formula

C25H22F3N5O4S

Molecular Weight

545.53

References & Citations

[1]Stevens T, et al. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339 (1) :313-20.|[2]Li H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2017 Nov 28;9 (2) :1772-1784.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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