Alvelestat (Standard)
Alvelestat (Standard) is the analytical standard of Alvelestat. This product is intended for research and analytical applications. Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].
Product Specifications
CAS Number
848141-11-7
UNSPSC
12352100
Target
Elastase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4
Molecular Formula
C25H22F3N5O4S
Molecular Weight
545.53
References & Citations
[1]Stevens T, et al. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339 (1) :313-20.|[2]Li H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2017 Nov 28;9 (2) :1772-1784.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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