(S) -Ruvonoflast
(S) -Ruvonoflast ((S) -NT-0796) is the S-isomer of Ruvonoflast (HY-156438) . Ruvonoflast (NT-0796) is an orally active, selective, centrally nervous system-transporting NLRP3 inflammasome inhibitor[1][2][3][4].
Product Specifications
Product Name Alternative
(S) -NT-0796
UNSPSC
12352005
Target
Drug Isomer
Related Pathways
Others
Field of Research
Neurological Disease
Purity
99.65
Smiles
CC(OC([C@H](CC1=NC=CC=N1)OC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)=O)C
Molecular Formula
C23H27N3O4
Molecular Weight
409.48
References & Citations
[1]David Harrison, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023 Oct 24.|[2]Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388 (3) :813-826. |[3]Smolak P, et al. Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency. J Pharmacol Exp Ther. 2024 Feb 15;388 (3) :798-812. |[4]Doedens JR, et al. The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1. Biochem Pharmacol. 2024 Sep;227:116455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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