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Capsazepine (Standard)

Capsazepine (Standard) is the analytical standard of Capsazepine. This product is intended for research and analytical applications. Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.

Product Specifications

CAS Number

138977-28-3

UNSPSC

12352100

Target

Apoptosis; Reference Standards; TRP Channel

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer

Smiles

S=C(N1CCCC2=CC(O)=C(O)C=C2C1)NCCC3=CC=C(Cl)C=C3

Molecular Formula

C19H21ClN2O2S

Molecular Weight

376.90

References & Citations

[1]Sung B, et al. Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic Biol Med. 2012 Nov 15;53 (10) :1977-87.|[2]Santicioli P, et al. Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH, capsaicin and potassium in rat soleus muscle. Br J Pharmacol. 1993 Oct;110 (2) :609-12.|[3]Cabral LD, et al. The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia. Basic Clin Pharmacol Toxicol. 2016 Nov;119 (5) :421-427.|[4]Wang J, et al. Anti-inflammatory and retinal protective effects of capsaicin on ischaemia-induced injuries through the release of endogenous somatostatin. Clin Exp Pharmacol Physiol. 2017 Jul;44 (7) :803-814.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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