MRS4654

MRS4654 is an efficient and neutral P2Y14R (hP2Y14R IC50 = 15.0 nM, mP2Y14R IC50 = 18.6 nM) antagonist. MRS4654 has analgesic and anti-inflammatory effects. MRS4654 can be used for research on asthma and neuropathic pain[1].

Product Specifications

CAS Number

[2765570-58-7]

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5=NOC(CO)=C5)C=C4)=C1)O

Molecular Formula

C28H18F3NO4

Molecular Weight

489.44

References & Citations

[1]Jung YH, et al. Structure-Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres. J Med Chem. 2021 Apr 22;64 (8) :5099-5122.