C2 Adamantanyl globotriaosylceramide (d18:1/2:0)

C2 Adamantanyl globotriaosylceramide (d18:1/2:0) (AdaGb3), a water-soluble globotriaosylceramide analog, is a bioactive sphingolipid. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) reverses MDR1-MDCK cell drug resistance. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) has high affinity for verotoxin (VT) [1][2].

Product Specifications

CAS Number

[261155-87-7]

Product Name Alternative

AdaGb3; Adamantyl Gb3; C2 Adamantanyl Ceramide Trihexoside (d18:1/2:0)

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O[C@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO)CO)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CC45CC6CC(CC(C6)C5)C4)=O

Molecular Formula

C48H83NO18

Molecular Weight

962.17

References & Citations

[1]De Rosa MF, et al. Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog. J Biol Chem. 2008 Feb 22;283 (8) :4501-11. |[2]Kamani M, et al. Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism. J Biol Chem. 2011 Jun 17;286 (24) :21413-26.