DNDI-0690

DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL) . DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and L. major CL. DNDI-0690 can be used for CL research[1].

Product Specifications

CAS Number

[2097881-13-3]

UNSPSC

12352209

Target

Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

FC(C=C1)=CC=C1C2=NC=C(C=C2)OC[C@@H]3OC4=NC([N+]([O-])=O)=CN4CC3

Molecular Formula

C18H15FN4O4

Molecular Weight

370.33

References & Citations

[1]Wijnant GJ, et al. Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis. Antimicrob Agents Chemother. 2019 Aug 23;63 (9) :e00829-19.