DNDI-0690
DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL) . DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and L. major CL. DNDI-0690 can be used for CL research[1].
Product Specifications
CAS Number
[2097881-13-3]
UNSPSC
12352209
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
FC(C=C1)=CC=C1C2=NC=C(C=C2)OC[C@@H]3OC4=NC([N+]([O-])=O)=CN4CC3
Molecular Formula
C18H15FN4O4
Molecular Weight
370.33
References & Citations
[1]Wijnant GJ, et al. Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis. Antimicrob Agents Chemother. 2019 Aug 23;63 (9) :e00829-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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