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MPTP (hydrochloride) (Standard)

Iproniazid (phosphate) (Standard) is the analytical standard of Iproniazid (phosphate) . This product is intended for research and analytical applications. Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity[1].

Product Specifications

CAS Number

23007-85-4

UNSPSC

12352005

Target

Apoptosis; Dopamine Receptor; Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Cancer

Smiles

CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl

Molecular Formula

C12H16ClN

Molecular Weight

209.72

References & Citations

[1]Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question) . Life Sci., 1985, 36, No. 3, 201-12.|[2]Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.|[3]Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13 (1) :180.|[4]Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc. 2007;2 (1) :141-51.|[5]Rabaneda-Lombarte N, et al. The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease. J Neuroinflammation. 2021 Apr 6;18 (1) :88. |[6]Lee, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019 Jan;26 (2) :213-228.|[7]Zhang QS, et al. Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38 (10) :1317-1328.|[8]Hammock BD, et al., A sheep model for MPTP induced Parkinson-like symptoms. Life Sci. 1989;45 (17) :1601-8.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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