Methylspinazarin
Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC50 = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase[1].
Product Specifications
CAS Number
[41768-12-1]
UNSPSC
12352005
Target
COMT
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Smiles
O=C1C(O)=C(C(C2=C(C(C)=CC(O)=C12)O)=O)O
Molecular Formula
C11H8O6
Molecular Weight
236.18
References & Citations
[1]H Chimura, et al. Letter: Methylspinazarin and dihydromethylspinazarin, catechol-O-methyl transferase inhibitors produced by Streptomyces. J Antibiot (Tokyo) . 1973 Feb;26 (2) :112-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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