NEP28
NEP28 is a selective androgen receptor modulator with an EC50 of 2.90 nM in 22RV1 cells. NEP28 increases the activity of Aβ-degrading enzyme neprilysin. NEP28 is efficacious in muscle and brain without serious side effects on prostate in rats. NEP28 can be used for osteoporosis, sarcopenia, and Alzheimer's disease research[1].
Product Specifications
CAS Number
[1254176-87-8]
UNSPSC
12352005
Target
Androgen Receptor; Neprilysin
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Neurological Disease
Smiles
N#CC=1SC(=CC1Br)N(CCC)CC(F)(F)F
Molecular Formula
C10H10BrF3N2S
Molecular Weight
327.16
References & Citations
[1]Akita K, et al. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. Eur J Pharmacol. 2013 Nov 15;720 (1-3) :107-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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