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NEP28

NEP28 is a selective androgen receptor modulator with an EC50 of 2.90 nM in 22RV1 cells. NEP28 increases the activity of Aβ-degrading enzyme neprilysin. NEP28 is efficacious in muscle and brain without serious side effects on prostate in rats. NEP28 can be used for osteoporosis, sarcopenia, and Alzheimer's disease research[1].

Product Specifications

CAS Number

1254176-87-8

UNSPSC

12352005

Target

Androgen Receptor; Neprilysin

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Neurological Disease

Smiles

N#CC=1SC(=CC1Br)N(CCC)CC(F)(F)F

Molecular Formula

C10H10BrF3N2S

Molecular Weight

327.16

References & Citations

[1]Akita K, et al. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. Eur J Pharmacol. 2013 Nov 15;720 (1-3) :107-14.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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