Vesatolimod (Standard)

Vesatolimod (Standard) is the analytical standard of Vesatolimod. This product is intended for research and analytical applications. Vesatolimod (GS-9620) is a potent, selective and orally active agonist of Toll-Like Receptor (TLR7) with an EC50 of 291 nM.

Product Specifications

CAS Number

[1228585-88-3]

UNSPSC

12352100

Target

Apoptosis; HBV; HCV; HIV; Reference Standards; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

O=C1NC2=C(N)N=C(OCCCC)N=C2N(CC3=CC=CC(CN4CCCC4)=C3)C1

Molecular Formula

C22H30N6O2

Molecular Weight

410.51

References & Citations

[1]Rebbapragada I, et al. Molecular Determinants of GS-9620-Dependent TLR7 Activation. PLoS One. 2016 Jan 19;11 (1) :e0146835.|[2]Lanford RE, et al. GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees. Gastroenterology. 2013 Feb 13. pii: S0016-5085 (13) 00169-8.|[3]D Tumas, et al. Preclinical Characterization of GS-9620, A Potent and Selective Oral TLR7 Agonist.