CCT368772

CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM) . CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM) [1]. CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer[2].

Product Specifications

CAS Number

[2902671-74-1]

UNSPSC

12352005

Target

Kinesin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

C(N[C@H](CC(NC=1SC(C(OCCC)=O)=C(C)N1)=O)CCCNC)(=O)C=2C=C(C=CC2)C=3N=C(C)ON3

Molecular Formula

C25H32N6O5S

Molecular Weight

528.63

References & Citations

[1]Saint-Dizier F, et al. Discovery of 2- (3-Benzamidopropanamido) thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. J Med Chem. 2023 Feb 23;66 (4) :2622-2645.|[2]Hans-Peter Buchstaller, et al. Substituted heterocycles as hset inhibitors. WO2023131690A1. 2023-07-13.