CCT368772
CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM) . CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM) [1]. CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer[2].
Product Specifications
CAS Number
2902671-74-1
UNSPSC
12352005
Target
Kinesin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
C(N[C@H](CC(NC=1SC(C(OCCC)=O)=C(C)N1)=O)CCCNC)(=O)C=2C=C(C=CC2)C=3N=C(C)ON3
Molecular Formula
C25H32N6O5S
Molecular Weight
528.63
References & Citations
[1]Saint-Dizier F, et al. Discovery of 2- (3-Benzamidopropanamido) thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. J Med Chem. 2023 Feb 23;66 (4) :2622-2645.|[2]Hans-Peter Buchstaller, et al. Substituted heterocycles as hset inhibitors. WO2023131690A1. 2023-07-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP
Frequently Asked Questions
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