(S) -Bleximenib
(S) -Bleximenib (Compound 28) ((S) -JNJ-75276617) is an isoform of Bleximenib (HY-148669) . (S) -Bleximenib shows an IC50 greater than 1 μM in the MEIS1 mRNA expression assay. (S) -Bleximenib can be used in the research of acute myeloid leukemia[1].
Product Specifications
CAS Number
[2654081-27-1]
Product Name Alternative
(S) -JNJ-75276617; (S) -Menin-MLL inhibitor 24
UNSPSC
12352005
Target
Drug Isomer; HOXA
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.0600
Smiles
COCCN(C)CCC[C@H](N1CC2(C1)CN(C3=NC=NN=C3OC4=C(C=C(C=C4)F)C(N(CC)C(C)C)=O)CC2)C(C)C
Molecular Formula
C32H50FN7O3
Molecular Weight
599.78
References & Citations
[1]Wei, et al. Substituted straight chain spiro derivatives. WO2021121327A1. WIPO (PCT) . 2020-12-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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