TNIR7-1A
TNIR7-1A is a fused cycloheptatriene–BODIPY derivative that displays properties favorable for near-infrared (NIR) imaging (Ex/Em = 600/774 nm in PBS) with high affinity and specificity to Neurofibrillary tangles (NFTs) in vitro. TNIR7-1A effectively penetrated the blood–brain barrier[1].
Product Specifications
CAS Number
2301931-35-9
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
[F-][B+3]1([N-]2C3=C(C=C2)C=CC(/C=C/C4=CC=C(C=C4)N(C)C)=CC3=C5[N]1=CC=C5)[F-]
Molecular Formula
C23H20BF2N3
Molecular Weight
387.23
References & Citations
[1]Tianxin Xie, et al. Fused Cycloheptatriene-BODIPY Is a High-Performance Near-Infrared Probe to Image Tau Tangles. J Med Chem. 2022 Nov 10;65 (21) :14527-14538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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