TNIR7-1A

TNIR7-1A is a fused cycloheptatriene–BODIPY derivative that displays properties favorable for near-infrared (NIR) imaging (Ex/Em = 600/774 nm in PBS) with high affinity and specificity to Neurofibrillary tangles (NFTs) in vitro. TNIR7-1A effectively penetrated the blood–brain barrier[1].

Product Specifications

CAS Number

[2301931-35-9]

UNSPSC

12352005

Target

Tau Protein

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

[F-][B+3]1([N-]2C3=C(C=C2)C=CC(/C=C/C4=CC=C(C=C4)N(C)C)=CC3=C5[N]1=CC=C5)[F-]

Molecular Formula

C23H20BF2N3

Molecular Weight

387.23

References & Citations

[1]Tianxin Xie, et al. Fused Cycloheptatriene-BODIPY Is a High-Performance Near-Infrared Probe to Image Tau Tangles. J Med Chem. 2022 Nov 10;65 (21) :14527-14538.