SM-122
SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP) -1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer[1].
Product Specifications
CAS Number
[874270-38-9]
UNSPSC
12352005
Target
Apoptosis; IAP
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C28H36N4O3
Molecular Weight
476.61
References & Citations
[1]Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68 (22) :9384-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CIAP-1; cIAP-2
Curated Selection
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