ALK/EGFR-IN-1-d5
ALK/EGFR-IN-1-d5 (Compound (-) -9a) is a deuterated dual-target inhibitor of EGFR and ALK, with an IC50 of 1.08 nM for EGFR and an IC50 of 2.395 nM for ALK. ALK/EGFR-IN-1-d5 inhibits the phosphorylated proteins in the EGFR, ALK, and BRK signaling pathways, blocking the cell cycle, leading to a reduction in mitochondrial membrane potential and cell apoptosis (Apoptosis) . ALK/EGFR-IN-1-d5 also significantly inhibits tumor growth in animal models and demonstrates good safety. ALK/EGFR-IN-1-d5 holds promise for research in the field of cancer treatment[1]
Product Specifications
CAS Number
2730429-93-1
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; BRK; EGFR; Isotope-Labeled Compounds; Mitochondrial Metabolism
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN(C)CCN(C1=C(C=C(C(OC)=C1)NC2=NC=C(Cl)C(NC3=C(C=CC=C3)S(C([2H])([2H])C([2H])([2H])[2H])=O)=N2)NC(C=C)=O)C
Molecular Formula
C27H29D5ClN7O3S
Molecular Weight
577.15
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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