SEA0400 (Standard)
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
Product Specifications
CAS Number
223104-29-8
UNSPSC
12352100
Target
Na+/Ca2+ Exchanger; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2
Molecular Formula
C21H19F2NO3
Molecular Weight
371.38
References & Citations
[1]Matsuda T, et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298 (1) :249-56.|[2]Nashida T, et al. The specific Na (+) /Ca (2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59 (1) :51-8.|[3]Ago Y, et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. 2011 Dec;61 (8) :1441-51.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC420346 20 µg
Sarcalumenin (SRL) (NM_001098814) Human Over-expression Lysate
Sign In for Pricing
View Details 
LY427281 100 µg
ZNF286 (ZNF286A) (NM_001130842) Human Over-expression Lysate
Sign In for Pricing
View Details 
GA100575 1 Kit
Human Actin RegULatory Protein CAPG (CAPG) activation kit by CRISPRa
Sign In for Pricing
View Details 
BNUM0988-50 1x 50 µL
CD54 (W-CAM-1; same as Wehi-CAM-1 or 1H4), 1mg/mL
Sign In for Pricing
View Details 