Semapimod (tetrahydrochloride)
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM) . Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
Product Specifications
CAS Number
164301-51-3
Product Name Alternative
CNI-1493; CPSI-2364 (tetrahydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Interleukin Related; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
98.43
Solubility
H2O : 2.17 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.Cl.Cl.Cl.Cl
Molecular Formula
C34H56Cl4N18O2
Molecular Weight
890.74
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IL-1; IL-6; p38 MAPK; TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
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