(3S) -Tanzisertib (hydrochloride)
(3S) -Tanzisertib (hydrochloride) ((3S) -CC-930 (hydrochloride) ) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively) . (3S) -Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC50 = 0.48, 3.4, and 0.38 μM, respectively) . (3S) -Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S) -Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research[1].
Product Specifications
CAS Number
[2517855-91-1]
Product Name Alternative
(3S) -CC-930 (hydrochloride)
UNSPSC
12352005
Target
EGFR; ERK; JNK; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
OC(CC1)CCC1NC2=NC=C3C(N([C@H]4CCOC4)C(NC5=C(C=C(C=C5F)F)F)=N3)=N2.Cl
Molecular Formula
C21H24ClF3N6O2
Molecular Weight
484.90
References & Citations
[1]Plantevin Krenitsky V, et al. Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg Med Chem Lett. 2012 Feb 1;22 (3) :1433-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; JNK1; JNK2; JNK3; p38α
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