13-O-Desmethyl tacrolimus

13-O-Desmethyl tacrolimus (13-DMT; 13-O-Demethyl FK 506) is the main metabolite of Tacrolimus (HY-13756) . 13-O-Desmethyl tacrolimus has a weak immunosuppressive activity. 13-O-Desmethyl tacrolimus is mainly used in the research on monitoring Tacrolimus (HY-13756) by monitoring the ratio of 13-DMT/Tacrolimus[1].

Product Specifications

CAS Number

[139958-51-3]

Product Name Alternative

13-DMT; 13-O-Demethyl FK 506

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

CO[C@@H]1[C@@]2([H])O[C@@](C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@@H](/C=C(C[C@@H](C1)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)([C@@H](C[C@@H]2O)C)O

Molecular Formula

C43H67NO12

Molecular Weight

789.99

References & Citations

[1]Zegarska J, et al. Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. Transplant Proc. 2018 Sep;50 (7) :2235-2239.